CE Mercadal have four games to save their place in the Tercera Division.
With four rounds to go in the Menorcan championship, CD Menorca are eight points clear at the top.
CE Alaior continued their perfect start to the Regional Preferente Menorca season with a 3-2 win over CD Migjorn.
CD Menorca will spend Christmas at the top of the Regional Preference Menorca league table after a 5-1 thumping of CCE Sant Lluis.
CE Mercadal are now seven games without a win in the Tercera Division after drawing 2-2 with Llosetense on Wednesday night.
There was a rare round of midweek action in the Regional Preferente Menorca.
Penya Ciutadella made it two wins from two at the start of the 2021/22 Regional Menorca Preferente season.
The new Menorca league season got underway at the weekend, with 11 teams battling for the top four promotion play-off spots.
UD Mahon smashed eight past Atletico Villacarlos to secure second place in the table.
After a COVID disrupted campaign, the Regional Preferente Menorca finishes its season this weekend.